Buy Bulk CJC-1295 NO-DAC 2mg
- Buy 50 for $15.95 each and save 73%
- Buy 100 for $13.95 each and save 76%
- Buy 200 for $12.95 each and save 78%
- Free Priority Shipping
- Orders over $75
Buy Bulk CJC-1295 NO-DAC (No Promo Codes):
| Unit Size | 2 mg/vial |
| Unit Quantity | 1 vial |
| Purity (Mass Spectrometry and UV) | 99.18% |
| Sequence | H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala- Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 |
| Molecular Formula | C152H252N44O42 |
| Appearance | Lyophilized White Powder |
| Source | Chemical Synthesis |
| Storage | Lyophilized CJC-1295 NO-DAC is Stable at room Temperature for 90 days, however it is best to store in a freezer below - 8c for any extended period of time. |
| Terms | The products we offer are intended for laboratory research use only. Please familiarize yourself with our terms of service prior to ordering. |
CJC-1295 NO-DAC 2mg (Bulk)
View Research Overview & References
CJC-1295 NO-DAC carries a molecular weight of approximately 3365.87 g/mol as the modified GRF(1-29) sequence without the albumin-binding drug affinity complex (DAC) used in a related CJC-1295 variant.
Continuous Versus Pulsatile Receptor Stimulation
A recurring question in GHRH receptor pharmacology is whether sustained receptor occupancy produces the same downstream signaling pattern as the brief, pulsatile stimulation characteristic of the native hormone.
Researchers studying long-acting GHRH analogs use this distinction to inform experimental design, since a compound's residence time at the receptor can shape signaling output independently of its binding affinity.
GHRH Receptor Structural Basis
Structural and computational research has characterized the GHRH receptor's dynamic conformational behavior, identifying molecular determinants of GHRH binding that provide a mechanistic basis for how CJC-1295 NO-DAC's retained GHRH-derived sequence engages this receptor in laboratory studies.1
Stabilizing Substitutions Relative to Native GRF
CJC-1295 NO-DAC carries four substitutions relative to native GRF(1-29): D-alanine at position 2 resists dipeptidyl peptidase-IV cleavage, glutamine at position 8 prevents deamidation, and alanine at position 15 together with a leucine substitution at position 27 reduce oxidation susceptibility.
These changes are the structural basis for the peptide's improved in vitro stability compared to unmodified GRF(1-29).
Analytical Purity Verification for Bulk Quantities
As a 29-residue peptide, CJC-1295 NO-DAC is more prone to synthesis-related impurities, such as deletion sequences, than shorter research peptides, making combined HPLC and mass spectrometry verification particularly important.
For bulk orders, researchers are encouraged to confirm that each production batch carries its own certificate of analysis, since a longer sequence increases the opportunity for batch-to-batch variation during synthesis.
Storage and Handling in the Laboratory Setting
The intact 29-residue sequence is more vulnerable to hydrolysis and aggregation once removed from its stable, freeze-dried state, making sub-zero freezer storage of the lyophilized powder standard laboratory practice.
Splitting a bulk shipment into multiple smaller sealed aliquots immediately upon receipt is standard practice, since this limits the number of times the full quantity is exposed to ambient temperature and humidity over the course of a study.
Important Notice
This product is intended strictly for in vitro laboratory research and is not suitable for human applications. These findings do not establish safety, efficacy, or suitability for any human application, and this product has not been evaluated by the FDA or any regulatory agency.
Product Information
CJC-1295 NO-DAC is supplied as a lyophilized powder at a concentration of 2 mg per vial, available in bulk quantity.
References
1. Matsoukas MT, Spyroulias GA. Dynamic properties of the growth hormone-releasing hormone receptor (GHRHR) and molecular determinants of GHRH binding. Mol Biosyst. 2017;13(7):1313-1322.
Login