Buy FRAGMENT 176-191 2mg
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Buy Bulk FRAGMENT 176-191 2mg (No Promo Codes):
| Unit Size | 2 mg/vial |
| Unit Quantity | 1 vial |
| Purity (Mass Spectrometry and UV) | 99.56% |
| Sequence | H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH |
| Molecular Formula | C78H123N23O23S2 |
| Appearance | Lyophilized White Powder |
| Source | Chemical Synthesis |
| Storage |
Lyophilized FRAGMENT 176-191 is Stable at room Temperature for 90 days, however it is best to storer in a freeze below - 8c for any extended period of time. |
| Terms | The products we offer are intended for laboratory research use only. Please familiarize yourself with our terms of service prior to ordering. |
FRAGMENT 176-191 2mg (Bulk)
View Research Overview & References
Fragment 176-191 isolates a 16-residue segment from the C-terminus of human growth hormone (hGH), a design that lets researchers study this specific region independent of the growth-promoting domains found elsewhere in the full-length hormone.
Structural Rationale for C-Terminal Isolation
The C-terminal domain of hGH is structurally and functionally distinct from the region responsible for stimulating insulin-like growth factor-1 (IGF-1) release, which resides elsewhere in the full-length molecule.1
By excluding the IGF-1-stimulating domain entirely, Fragment 176-191 allows researchers to study this C-terminal region's signaling in cell-based systems without the confounding variable of concurrent IGF-1 elevation seen with full-length hGH.
Sequence Modifications Relative to the Native C-Terminus
Fragment 176-191 differs from the unmodified, naturally occurring hGH C-terminal region through a tyrosine-for-phenylalanine substitution and an added N-terminal tyrosine, distinguishing it from earlier linear fragment designs studied in the literature.
In Vitro Genetic Toxicology Screening
Standard laboratory genotoxicity screening for this hGH fragment has included a bacterial reverse mutation assay and a cultured mammalian cell chromosomal aberration test, alongside general cytotoxicity screening in cell-based systems.2
Analytical Documentation for Bulk Quantities
Variation in counterion content, commonly acetate from the HPLC purification process, can affect net peptide content per milligram of lyophilized powder even at a constant purity percentage.
For bulk orders spanning multiple production batches, researchers designing experiments that depend on precise molar concentration are encouraged to consult lot-specific certificates of analysis, which typically report peptide content alongside purity, rather than assuming uniformity across the full order.
Storage and Handling in the Laboratory Setting
The disulfide bond between Fragment 176-191's two cysteine residues is susceptible to reduction under certain storage conditions, particularly with reducing agents or extended exposure to light and elevated temperature.
Lyophilized storage under sub-zero freezer conditions helps preserve this oxidized state, and a bulk order is best split into a handful of smaller sealed vials as soon as it arrives, rather than reopening one large container throughout a series of experiments.
Important Notice
This product is intended for laboratory research use (in vitro) only. It is not approved for human use under any circumstances, and has not been evaluated for safety or efficacy in humans.
Product Information
Fragment 176-191 is supplied as a research reagent for laboratory use only, available in bulk quantity.
References
1. Harvey S, Martinez-Moreno CG. Growth Hormone: Therapeutic Possibilities—An Overview. Int J Mol Sci. 2018;19(7):2015.
2. Moré MI, Kenley D. Safety and metabolism of AOD9604, a novel nutraceutical ingredient for improved metabolic health. J Endocrinol Metab. 2014;4(3):64-77.
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