Buy Bulk CJC-1295 W-DAC 2mg
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Buy Bulk CJC-1295 W-DAC 2mg (No Promo Codes):
| Unit Size | 2 mg/vial |
| Unit Quantity | 1 vial |
| Purity (Mass Spectrometry and UV) | 96.0% |
| Sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Maleimidopropionyl)-NH2 |
| Molecular Formula | C165H269N47O46 |
| Appearance | Lyophilized White Powder |
| Source | Chemical Synthesis |
| Storage | Lyophilized CJC 1295 DAC is Stable at room Temperature for 90 days, however it is best to store in a freezer below - 8c for any extended period of time. |
| Terms | The products we offer are intended for laboratory research use only. Please familiarize yourself with our terms of service prior to ordering. |
CJC-1295 W-DAC 2mg (Bulk)
View Research Overview
CJC-1295 with DAC extends the GRF(1-29) analog scaffold with a drug affinity complex (DAC): a terminal lysine residue conjugated to a maleimidopropionyl group, distinguishing it structurally from the NO-DAC variant of this same analog.
Albumin Conjugation Mechanism
The maleimide group is designed to form a covalent bond with the free thiol of cysteine-34 on circulating serum albumin, tethering the peptide to one of the most abundant and slowly cleared proteins in blood.
This conjugation strategy shifts the pharmacokinetic profile from the internal sequence modifications relied upon by unconjugated GRF(1-29) analogs toward a fundamentally different half-life extension mechanism.
Structural Comparison to the NO-DAC Variant
Both this compound and its NO-DAC counterpart share the same 29-residue GRF-derived backbone, including the D-alanine, glutamine, alanine, and leucine substitutions that stabilize the sequence itself against enzymatic and chemical degradation.
The DAC-conjugated version adds the maleimidopropionyl-lysine extension on top of these existing stabilizing substitutions, meaning the two mechanisms work independently rather than one replacing the other.
Analytical Verification of the Maleimide Group
Because the maleimide group is the functional basis for this peptide's albumin-binding capability, analytical verification typically goes beyond standard sequence and purity confirmation to include mass-spectrometric confirmation that the group remains intact and unreacted.
A hydrolyzed maleimide group would compromise albumin-binding capacity without necessarily changing the peptide's overall mass in a way that basic purity testing alone would catch.
For bulk orders, researchers are encouraged to confirm that this maleimide-specific analytical data is reported for the batch supplied, not only an aggregate purity figure.
Storage and Handling in the Laboratory Setting
The reactive maleimide group is more sensitive to hydrolysis in aqueous environments than the peptide backbone itself, making moisture control an additional consideration beyond standard cold storage.
The lyophilized powder is kept under sub-zero freezer conditions in sealed, moisture-limited packaging given the maleimide group's added sensitivity to humidity.
With a bulk order, the received quantity is best broken down into multiple smaller sealed vials right away, since this keeps most of the material untouched and protected while only one vial is opened at a time for active use.
Important Notice
CJC-1295 with DAC is intended strictly for in vitro laboratory research only and is not approved for human use. All handling and experimentation must occur in compliance with applicable laboratory research protocols, and this product has not been evaluated for safety or efficacy in humans.
Product Information
CJC-1295 with DAC is available as a lyophilized powder at a concentration of 2 mg per vial, available in bulk quantity.
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